Article
SERPINA1 Hepatocyte-Specific Promoter Polymorphism Associate with Chronic Obstructive Pulmonary Disease in a Study of Kashmiri Ancestry Individuals.
Lung - 1 Aug 2018
Bashir Arif, Hazari Younis M, Bashir Samirul, Hilal Nazia, Banday Mariam, Iqbal Mir Khurshid, Jan Tariq Rashid, Farooq Syed Suraiya, Shah Naveed Nazir, Fazili Khalid Majid
Abstract excerpt
PURPOSE: Different mutations in coding and non-coding sequences of the SERPINA1 gene have been implicated in the pathogenesis of COPD. However, - 10T/C mutation in the hepatocyte-directed promoter region has not been associated with COPD pathogenesis so far. Here, we report an increased frequency of - 10C genotype that is associated with decreased levels of serum alpha1-antitrypsin (α1AT) in COPD patients....
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