Relevance of MTHFR polymorphisms with response to fluoropyrimidine-based chemotherapy in oesophagogastric cancer: a meta-analysis.

doi:10.1136/bmjopen-2017-020767

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Article

Relevance of MTHFR polymorphisms with response to fluoropyrimidine-based chemotherapy in oesophagogastric cancer: a meta-analysis.

BMJ open - 26 May 2018

Zhong Lei, Fu Qi, Zhou Shu, Chen Lu, Peng Qian

Abstract excerpt

OBJECTIVE: To evaluate the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the response to fluoropyrimidine-based chemotherapy in oesophagogastric cancer. DESIGN: Meta-analysis. METHODS: We searched PubMed, Embase and Web of Science databases from inception up to October 2017 for relevant studies. The statistical analysis was performed using STATA V.12.0 software. The pooled ORs...

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Identifiers

PMID: 29804062
DOI: 10.1136/bmjopen-2017-020767
PMCID: PMC5988135

Genes

MTHFR

Variants

rs1801133
rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.