Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation.

doi:10.1038/s41467-018-04455-7

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Article

Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation.

Nature communications - 25 May 2018

Tatavosian Roubina, Duc Huy Nguyen, Huynh Thao Ngoc, Fang Dong, Schmitt Benjamin, Shi Xiaodong, Deng Yiming, Phiel Christopher, Yao Tingting, Zhang Zhiguo, Wang Haobin, Ren Xiaojun

Abstract excerpt

Over 80% of diffuse intrinsic pontine gliomas (DIPGs) harbor a point mutation in histone H3.3 where lysine 27 is substituted with methionine (H3.3K27M); however, how the mutation affects kinetics and function of PcG proteins remains elusive. We demonstrate that H3.3K27M prolongs the residence time and search time of Ezh2, but has no effect on its fraction bound to chromatin. In contrast, H3.3K27M has no effect on...

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PMID: 29802243
DOI: 10.1038/s41467-018-04455-7
PMCID: PMC5970213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.