Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins.

doi:10.1016/j.dnarep.2018.05.003

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Article

Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins.

DNA repair - 1 Aug 2018

Maity Jyotirindra, Das Biswadip, Bohr Vilhelm A, Karmakar Parimal

Abstract excerpt

Impaired autophagy may be associated with normal and pathological aging. Here we explore a link between autophagy and domain function of Werner protein (WRNp). Werner (WRN) mutant cell lines AG11395, AG05229 and normal aged fibroblast AG13129 display a deficient response to tunicamycin mediated endoplasmic reticulum (ER) stress induced autophagy compared to clinically unaffected GM00637 and normal young...

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PMID: 29800817
DOI: 10.1016/j.dnarep.2018.05.003
PMCID: PMC6338341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.