Nucleoside analogs to manage sequence divergence in nucleic acid amplification and SNP detection.

doi:10.1093/nar/gky392

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Article

Nucleoside analogs to manage sequence divergence in nucleic acid amplification and SNP detection.

Nucleic acids research - 6 Jul 2018

Yang Zunyi, Kim Hyo-Joong, Le Jennifer T, McLendon Chris, Bradley Kevin M, Kim Myong-Sang, Hutter Daniel, Hoshika Shuichi, Yaren Ozlem, Benner Steven A

Abstract excerpt

Described here are the synthesis, enzymology and some applications of a purine nucleoside analog (H) designed to have two tautomeric forms, one complementary to thymidine (T), the other complementary to cytidine (C). The performance of H is compared by various metrics to performances of other 'biversal' analogs that similarly rely on tautomerism to complement both pyrimidines. These include (i) the thermodynamic...

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Identifiers

PMID: 29800323
DOI: 10.1093/nar/gky392
PMCID: PMC6159519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.