Article
Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients.
Nature communications - 24 May 2018
Wang Cheng, Yin Rong, Dai Juncheng, Gu Yayun, Cui Shaohua, Ma Hongxia, Zhang Zhihong, Huang Jiaqi, Qin Na, Jiang Tao, Geng Liguo, Zhu Meng, Pu Zhening, Du Fangzhi, Wang Yuzhuo, Yang Jianshui, Chen Liang, Wang Qianghu, Jiang Yue, Dong Lili, Yao Yihong, Jin Guangfu, Hu Zhibin, Jiang Liyan, Xu Lin, Shen Hongbing
Abstract excerpt
Chinese lung cancer patients have distinct epidemiologic and genomic features, highlighting the presence of specific etiologic mechanisms other than smoking. Here, we present a comprehensive genomic landscape of 149 non-small cell lung cancer (NSCLC) cases and identify 15 potential driver genes. We reveal that Chinese patients are specially characterized by not only highly clustered EGFR mutations but a...
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