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Article

Pituitary resistance to thyroid hormone caused by a novel mutation (H435A) in the thyroid hormone receptor beta: A case report.

Medicine - 1 May 2018

Yu Changzhen, Zhao Junyu, Yao Jinming, Wang Huanjun, Shang Hongxia, Zhang Rui, Cui Yujiao, Wang Likang, Dong Jianjun, Liao Lin

Abstract excerpt

RATIONALE: In patients with pituitary thyroid hormone resistance, the ability of the pituitary gland to detect (and down-regulate) the increase of triiodothyronine is selectively impaired, while the periphery remains sensitive to triiodothyronine levels, producing symptoms of peripheral thyrotoxicity. Subsequently, there is no feedback of pituitary production of thyroid-stimulating hormone (TSH), which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29794730
DOI: 10.1097/MD.0000000000010544
PMCID: PMC6392742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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