Article
Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.
Nature communications - 22 May 2018
Xiao Yao, Wang Can, Chen Jia-Yu, Lu Fujian, Wang Jue, Hou Ning, Hu Xiaomin, Zeng Fanxin, Ma Dongwei, Sun Xueting, Ding Yi, Zhang Yan, Zheng Wen, Liu Yuli, Shang Haibao, Zhu Wenzhen, Han Chensheng, Zhang Yulin, Ouyang Kunfu, Chen Liangyi, Chen Ju, Xiao Rui-Ping, Li Chuan-Yun, Zhang Xiuqin
Abstract excerpt
Hyperinsulinemia is the earliest symptom of insulin resistance (IR), but a causal relationship between the two remains to be established. Here we show that a protein kinase D2 (PRKD2) nonsense mutation (K410X) in two rhesus monkeys with extreme hyperinsulinemia along with IR and metabolic defects by using extreme phenotype sampling and deep sequencing analyses. This mutation reduces PRKD2 at both the mRNA and the...
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