Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification.

doi:10.1371/journal.pone.0196204

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Article

Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification.

PloS one - 1 Jan 2018

Tsuru Michiyo, Ono Atsushi, Umeyama Hideaki, Takeuchi Masahiro, Nagata Kensei

Abstract excerpt

Ossification of the posterior longitudinal ligament (OPLL), a spinal ligament, reduces the range of motion in limbs. No treatment is currently available for OPLL, which is why therapies are urgently needed. OPLL occurs in obesity, is more common in men, and has an onset after 40 years of age. The mechanisms underlying OPLL remain unclear. In this study, we performed a serum proteomic analysis in both OPLL...

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Identifiers

PMID: 29782494
DOI: 10.1371/journal.pone.0196204
PMCID: PMC5962073

Genes

UCHL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.