Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.

doi:10.1016/j.jmb.2018.05.017

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Article

Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.

Journal of molecular biology - 6 Jul 2018

Cui Gaofeng, Botuyan Maria Victoria, Mer Georges

Abstract excerpt

REV1 is an evolutionarily conserved translesion synthesis (TLS) DNA polymerase and an assembly factor key for the recruitment of other TLS polymerases to DNA damage sites. REV1-mediated recognition of ubiquitin in the proliferative cell nuclear antigen is thought to be the trigger for TLS activation. Here we report the solution NMR structure of a 108-residue fragment of human REV1 encompassing the two putative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29778604
DOI: 10.1016/j.jmb.2018.05.017
PMCID: PMC6043352

Genes

REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.