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Article

The full-length microRNA cluster in the intron of large latency transcript is associated with the virulence of pseudorabies virus.

Virology - 1 Jul 2018

Wang Xin, Zhang Mei-Mei, Yan Kai, Tang Qi, Wu Yi-Quan, He Wen-Bo, Chen Huan-Chun, Liu Zheng-Fei

Abstract excerpt

Pseudorabies virus (PRV), the etiological pathogen of Aujeszky's disease, belongs to the Alphaherpesvirus subfamily. Large latency transcript (LLT), the most abundant PRV transcript, harbors a ~ 4.6 kb microRNA (miRNA) cluster-encoding intron. To investigate the function of the LLT miRNA cluster during the life cycle of PRV, we generated a miRNA cluster mutation virus (PRV-∆miR cluster) and revertant virus....

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Identifiers

PMID: 29777914
DOI: 10.1016/j.virol.2018.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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