A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs.

doi:10.1101/gad.314856.118

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Article

A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs.

Genes & development - 1 May 2018

Huang Chuan, Liang Dongming, Tatomer Deirdre C, Wilusz Jeremy E

Abstract excerpt

Circular RNAs (circRNAs) are generated from many protein-coding genes. Most accumulate in the cytoplasm, but how circRNA localization or nuclear export is controlled remains unclear. Using RNAi screening, we found that depletion of the Drosophila DExH/D-box helicase Hel25E results in nuclear accumulation of long (>800-nucleotide), but not short, circRNAs. The human homologs of Hel25E similarly regulate circRNA...

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Identifiers

PMID: 29773557
DOI: 10.1101/gad.314856.118
PMCID: PMC6004072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.