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Article

Next-generation sequencing in drug development: target identification and genetically stratified clinical trials.

Drug discovery today - 1 Oct 2018

Doostparast Torshizi Abolfazl, Wang Kai

Abstract excerpt

Next-generation sequencing (NGS) enabled high-throughput analysis of genotype-phenotype relationships on human populations, ushering in a new era of genetics-informed drug development. The year 2017 was remarkable, with the first FDA-approved gene therapy for cancer (Kymriah™) and for inherited diseases (LUXTURNA™), the first multiplex NGS panel for companion diagnostics (MSK-IMPACT™) and the first drug targeting...

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PMID: 29758342
DOI: 10.1016/j.drudis.2018.05.015

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IMPACT

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