Article
Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy.
Cancer cytopathology - 1 Aug 2018
Schaefer Inga-Marie, Fletcher Jonathan A, Nielsen G Petur, Shih Angela R, Ferrone Marco L, Hornick Jason L, Qian Xiaohua
Abstract excerpt
BACKGROUND: Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but are absent in histologic mimics. Mutation-specific immunohistochemistry (IHC) is highly specific...
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