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Article

The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA.

Cell death & disease - 1 May 2018

Li Ming, Xie Zhongyu, Wang Peng, Li Jinteng, Liu Wenjie, Tang Su'an, Liu Zhenhua, Wu Xiaohua, Wu Yanfeng, Shen Huiyong

Abstract excerpt

Mesenchymal stem cells (MSCs) are important pluripotent stem cells and a major source of adipocytes in the body. However, the mechanism of adipogenic differentiation has not yet been completely elucidated. In this study, the long noncoding RNA GAS5 was found to be negatively correlated with MSC adipogenic differentiation. GAS5 overexpression negatively regulated adipocyte formation, whereas GAS5 knockdown had the...

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Source

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Identifiers

PMID: 29748618
DOI: 10.1038/s41419-018-0627-5
PMCID: PMC5945827

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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