Brown adipose tissue plays a central role in systemic inflammation-induced sleep responses.

doi:10.1371/journal.pone.0197409

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Article

Brown adipose tissue plays a central role in systemic inflammation-induced sleep responses.

PloS one - 1 Jan 2018

Szentirmai Éva, Kapás Levente

Abstract excerpt

We previously identified brown adipose tissue (BAT) as a source of sleep-inducing signals. Pharmacological activation of BAT enhances sleep while sleep loss leads to increased BAT thermogenesis. Recovery sleep after sleep loss is diminished in mice that lack uncoupling protein 1 (UCP-1), and also in wild-type (WT) mice after sensory denervation of the BAT. Systemic inflammation greatly affects metabolism and the...

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Identifiers

PMID: 29746591
DOI: 10.1371/journal.pone.0197409
PMCID: PMC5945014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.