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Article

Identification of novel drug targets for diamond-blackfan anemia based on RPS19 gene mutation using protein-protein interaction network.

BMC systems biology - 24 Apr 2018

Khan Abbas, Ali Arif, Junaid Muhammad, Liu Chang, Kaushik Aman Chandra, Cho William C S, Wei Dong-Qing

Abstract excerpt

BACKGROUND: Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents in infancy. In order to explore the molecular mechanisms of wild and mutated samples from DBA patients were exposed to bioinformatics investigation. Biological network of differentially expressed genes was constructed. This study aimed to identify novel therapeutic signatures in DBA and uncovered their mechanisms....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29745857
DOI: 10.1186/s12918-018-0563-0
PMCID: PMC5998885

Genes

AKT1
CCR2
EGR1
NFKB1
RAC1
RAC3
RELA
RPS19
STAT1
STAT3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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