Article
Focal segmental glomerulosclerosis with heterozygous apolipoprotein E5 (Glu3Lys).
CEN case reports - 1 Nov 2018
Sasaki Masaru, Yasuno Tetsuhiko, Ito Kenji, Matsunaga Akira, Hisano Satoshi, Abe Yasuhiro, Miyake Katsuhisa, Masutani Kosuke, Nakashima Hitoshi, Saito Takao
Abstract excerpt
Apolipoprotein (apo) E5 is a rare apoE isoform. The apoE5 (Glu3Lys) variant, which is caused by the substitution of lysine with glutamic acid at codon 3, has a relative frequency of 0.1% in Japan. Previous studies have reported that apoE5 (Glu3Lys) is associated with hyperlipidemia and cardiovascular diseases, but this isoform has higher LDL receptor-binding activity than that of normal apoE3. Nephropathy...
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