Article
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.
Diabetes - 1 Jul 2018
Abderrahmani Amar, Yengo Loïc, Caiazzo Robert, Canouil Mickaël, Cauchi Stéphane, Raverdy Violeta, Plaisance Valérie, Pawlowski Valérie, Lobbens Stéphane, Maillet Julie, Rolland Laure, Boutry Raphael, Queniat Gurvan, Kwapich Maxime, Tenenbaum Mathie, Bricambert Julien, Saussenthaler Sophie, Anthony Elodie, Jha Pooja, Derop Julien, Sand Olivier, Rabearivelo Iandry, Leloire Audrey, Pigeyre Marie, Daujat-Chavanieu Martine, Gerbal-Chaloin Sabine, Dayeh Tasnim, Lassailly Guillaume, Mathurin Philippe, Staels Bart, Auwerx Johan, Schürmann Annette, Postic Catherine, Schafmayer Clemens, Hampe Jochen, Bonnefond Amélie, Pattou François, Froguel Philippe
Abstract excerpt
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers from patients with T2D compared with livers of individuals with normal plasma glucose levels can unveil some mechanism of hepatic insulin resistance that could link to NAFLD. Using DNA methylome and transcriptome analyses of...
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