Article
Asthma and allergic rhinitis associate with the rs2229542 variant that induces a p.Lys90Glu mutation and compromises AKR1B1 protein levels.
Human mutation - 1 Aug 2018
García-Martín Elena, Sánchez-Gómez Francisco J, Amo Gemma, García Menaya Jesús, Cordobés Concepción, Ayuso Pedro, Plaza Serón M Carmen, Blanca Miguel, Campo Paloma, Esguevillas Gara, Pajares María A, G Agúndez José A, Pérez-Sala Dolores
Abstract excerpt
Asthma and rhinitis are two of the main clinical manifestations of allergy, in which increased reactive oxygen or electrophilic species can play a pathogenic role. Aldose reductase (AKR1B1) is involved in aldehyde detoxification and redox balance. Recent evidence from animal models points to a role of AKR1B1 in asthma and rhinitis, but its involvement in human allergy has not been addressed. Here, the putative...
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