Article
A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.
European heart journal - 14 Aug 2018
Rivaud Mathilde R, Jansen John A, Postema Pieter G, Nannenberg Eline A, Mizusawa Yuka, van der Nagel Roel, Wolswinkel Rianne, van der Made Ingeborg, Marchal Gerard A, Rajamani Sridharan, Belardinelli Luiz, van Tintelen J Peter, Tanck Michael W T, van der Wal Allard C, de Bakker Jacques M T, van Rijen Harold V, Creemers Esther E, Wilde Arthur A M, van den Berg Maarten P, van Veen Toon A B, Bezzina Connie R, Remme Carol Ann
Abstract excerpt
Aims: Management of patients with inherited cardiac ion channelopathy is hindered by variability in disease severity and sudden cardiac death (SCD) risk. Here, we investigated the modulatory role of hypertrophy on arrhythmia and SCD risk in sodium channelopathy. Methods and results: Follow-up data was collected from 164 individuals positive for the SCN5A-1795insD founder mutation and 247 mutation-negative...
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