αA-crystallin-derived minichaperone stabilizes αAG98R-crystallin by affecting its zeta potential.

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Article

αA-crystallin-derived minichaperone stabilizes αAG98R-crystallin by affecting its zeta potential.

Molecular vision - 1 Jan 2018

Phadte Ashutosh S, Santhoshkumar Puttur, Sharma K Krishna

Abstract excerpt

Purpose: The G98R mutant of αA-crystallin is associated with the development of presenile cataracts. In vitro, the recombinant mutant protein exhibits altered structural and functional characteristics, along with the propensity to aggregate by itself and precipitate. Previously, we have reported that the N-terminal aspartate substituted form of the antiaggregation peptide, D71FVIFLDVKHFSPEDLTVK88...

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Identifiers

PMID: 29706763
PMCID: PMC5906106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.