Article
Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells by mTOR activation through Akt-independent pathway.
Cancer science - 1 Jun 2018
Yamazaki Shota, Higuchi Youichi, Ishibashi Masayuki, Hashimoto Hiroko, Yasunaga Masahiro, Matsumura Yasuhiro, Tsuchihara Katsuya, Tsuboi Masahiro, Goto Koichi, Ochiai Atsushi, Ishii Genichiro
Abstract excerpt
Primary resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is a serious problem in lung adenocarcinoma patients harboring EGFR mutations. The aim of this study was to examine whether and how collagen type I (Col I), the most abundantly deposited matrix in tumor stroma, affects EGFR-TKI sensitivity in EGFR-mutant cells. We evaluated the EGFR-TKI sensitivity of EGFR-mutated cancer...
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