Article
Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients.
British journal of cancer - 1 May 2018
Bins Sander, Basak Edwin A, El Bouazzaoui Samira, Koolen Stijn L W, Oomen-de Hoop E, van der Leest Cor H, van der Veldt Astrid A M, Sleijfer Stefan, Debets Reno, van Schaik Ron H N, Aerts Joachim G J V, Mathijssen Ron H J
Abstract excerpt
BACKGROUND: Treatment with PD-1 inhibitors can be hampered by severe auto-immune-related toxicities. Our objective was to identify single-nucleotide polymorphisms (SNPs) in genes previously associated with auto-immunity, which are associated with toxicities in nivolumab-treated NSCLC patients. This was in order to identify patients prone to develop severe toxicities and to gain more insight into the underlying...
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