Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia.

doi:10.1182/blood-2018-03-837781

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Article

Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia.

Blood - 12 Jul 2018

Itzykson Raphael, Duployez Nicolas, Fasan Annette, Decool Gauthier, Marceau-Renaut Alice, Meggendorfer Manja, Jourdan Eric, Petit Arnaud, Lapillonne Hélène, Micol Jean-Baptiste, Cornillet-Lefebvre Pascale, Ifrah Norbert, Leverger Guy, Dombret Hervé, Boissel Nicolas, Haferlach Torsten, Preudhomme Claude

Abstract excerpt

Mutations in receptor tyrosine kinase/RAS signaling pathway genes are frequent in core-binding factor (CBF) acute myeloid leukemias (AMLs), but their prognostic relevance is debated. A subset of CBF AML patients harbors several signaling gene mutations. Genotyping of colonies and of relapse samples indicates that these arise in independent clones, thus defining a process of clonal interference (or parallel...

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