Article
Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques.
Alzheimer's research & therapy - 24 Apr 2018
Zhou Feng-Qin, Jiang Juan, Griffith Chelsea M, Patrylo Peter R, Cai Huaibin, Chu Yaping, Yan Xiao-Xin
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is a devastating neurodegenerative disorder bearing multiple pathological hallmarks suggestive of complex cellular/molecular interplay during pathogenesis. Transgenic mice and nonhuman primates are used as disease models for mechanistic and translational research into AD; the extent to which these animal models recapitulate AD-type neuropathology is an issue of importance....
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