Article
High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/- Mice.
The American journal of pathology - 1 Jul 2018
Kuwahara Yasumichi, Kennedy Leslie M, Karnezis Anthony N, Mora-Blanco E Lorena, Rogers Arlin B, Fletcher Christopher D, Huntsman David G, Roberts Charles W M, Rathmell W Kimryn, Weissman Bernard E
Abstract excerpt
The new paradigm of mutations in chromatin-modifying genes as driver events in the development of cancers has proved challenging to resolve the complex influences over disease phenotypes. In particular, impaired activities of members of the SWI/SNF chromatin remodeling complex have appeared in an increasing variety of tumors. Mutations in SNF5, a member of this ubiquitously expressed complex, arise in almost all...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
