Article
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.
PloS one - 1 Jan 2018
Ladds Marcus J G W, Pastor-Fernández Andrés, Popova Gergana, van Leeuwen Ingeborg M M, Eng Kai Er, Drummond Catherine J, Johansson Lars, Svensson Richard, Westwood Nicholas J, McCarthy Anna R, Tholander Fredrik, Popa Mihaela, Lane David P, McCormack Emmet, McInerney Gerald M, Bhatia Ravi, Laín Sonia
Abstract excerpt
Tenovin-6 is the most studied member of a family of small molecules with antitumour activity in vivo. Previously, it has been determined that part of the effects of tenovin-6 associate with its ability to inhibit SirT1 and activate p53. However, tenovin-6 has also been shown to modulate autophagic flux. Here we show that blockage of autophagic flux occurs in a variety of cell lines in response to certain...
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