Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome.

Frontiers in immunology - 1 Jan 2018

Asano Takaki, Okada Satoshi, Tsumura Miyuki, Yeh Tzu-Wen, Mitsui-Sekinaka Kanako, Tsujita Yuki, Ichinose Youjiro, Shimada Akira, Hashimoto Kunio, Wada Taizo, Imai Kohsuke, Ohara Osamu, Morio Tomohiro, Nonoyama Shigeaki, Kobayashi Masao

Abstract excerpt

Activated PI3Kδ syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory tract infections, lymphoproliferation, and defective IgG production. Heterozygous mutations in PIK3CD, PIK3R1, or PTEN, which are related to the hyperactive phosphoinositide 3-kinase (PI3K) signaling, were recently presented to cause APDS1 or APDS2 (APDSs), or APDS-like (APDS-L) disorder. In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class Ia Phosphatidylinositol 3-Kinase

Share to Immunologic Deficiency Syndromes

Share to Phosphatidylinositol 3-Kinases

Share to Phosphorylation

Share to Precursor Cells, B-Lymphoid

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 29675019
DOI: 10.3389/fimmu.2018.00568
PMCID: PMC5895775

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome.PMID 29675019Read ↗

Activated PI3Kinase Delta Syndrome—A Multifaceted DiseaseSemantic proximity Read ↗

Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections.Semantic proximity Read ↗

Disorders Related to PI3Kδ Hyperactivation: Characterizing the Clinical and Immunological Features of Activated PI3-Kinase Delta SyndromesSemantic proximity Read ↗

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.Semantic proximity Read ↗

Identification of a novel de novo gain-of-function mutation of PIK3CD in a patient with activated phosphoinositide 3-kinase δ syndrome.Semantic proximity Read ↗

Activated PI3Kδ syndrome type 2: Two patients, a novel mutation, and review of the literature.Semantic proximity Read ↗

The Treatment of Activated PI3Kδ SyndromeSemantic proximity Read ↗

The First Iranian Cohort of Pediatric Patients with Activated Phosphoinositide 3-Kinase-δ (PI3Kδ) Syndrome (APDS).Semantic proximity Read ↗

Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy.Semantic proximity Read ↗

[Clinical and immunological analysis of patients with activated phosphoinositide 3-kinase δ syndrome resulting from PIK3CD mutation].Semantic proximity Read ↗

Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene.Semantic proximity Read ↗

PI3Kδ and primary immunodeficiencies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.