Article
Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease.
Organic & biomolecular chemistry - 21 Apr 2012
Wang Guan-Nan, Twigg Gabriele, Butters Terry D, Zhang Siwei, Zhang Liangren, Zhang Li-He, Ye Xin-Shan
Abstract excerpt
A series of N-substituted ε-hexonolactams have been designed and prepared by a concise route with a tandem ring-expansion reaction as the key step. Some of the N-substituted ε-hexonolactams show better enhancements to N370S mutant β-glucocerebrosidase activity than NB-DNJ and NN-DNJ. Both the exp...
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