Article
Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system.
Neuro-oncology - 2 Aug 2018
Linninger Andreas, Hartung Grant A, Liu Benjamin P, Mirkov Snezana, Tangen Kevin, Lukas Rimas V, Unruh Dusten, James C David, Sarkaria Jann N, Horbinski Craig
Abstract excerpt
Background: Among diffusely infiltrative gliomas in adults, 20%-30% contain a point mutation in isocitrate dehydrogenase 1 (IDH1mut), which increases production of D-2-hydroxyglutarate (D2HG). This is so efficient that D2HG often reaches 30 mM within IDH1mut gliomas. Yet, while up to 100 µM D2HG can be detected in the circulating cerebrospinal fluid of IDH1mut glioma patients, the exposure of nonneoplastic cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.