Article
Single nucleotide variant counts computed from RNA sequencing and cellular traffic into human kidney allografts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Oct 2018
Thareja Gaurav, Yang Hua, Hayat Shahina, Mueller Franco B, Lee John R, Lubetzky Michelle, Dadhania Darshana M, Belkadi Aziz, Seshan Surya V, Suhre Karsten, Suthanthiran Manikkam, Muthukumar Thangamani
Abstract excerpt
Advances in bioinformatics allow identification of single nucleotide polymorphisms (variants) from RNA sequence data. In an allograft biopsy, 2 genomes contribute to the RNA pool, 1 from the donor organ and the other from the infiltrating recipient's cells. We hypothesize that imbalances in genetic variants of RNA sequence data of kidney allograft biopsies provide an objective measure of cellular infiltration of...
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