Article
Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.
Biochimica et biophysica acta. Molecular and cell biology of lipids - 1 Jul 2018
Bickert Andreas, Kern Paul, van Uelft Martina, Herresthal Stefanie, Ulas Thomas, Gutbrod Katharina, Breiden Bernadette, Degen Joachim, Sandhoff Konrad, Schultze Joachim L, Dörmann Peter, Hartmann Dieter, Bauer Reinhard, Willecke Klaus
Abstract excerpt
The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level. We show here by qRT-PCR and transcriptome analyses that several transcripts of genes involved in lipid metabolism and cell division are differentially...
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