The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.

doi:10.1074/jbc.RA118.002727

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Article

The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.

The Journal of biological chemistry - 18 May 2018

Tang Yan, Kwon Hyokjoon, Neel Brian A, Kasher-Meron Michal, Pessin Jacob B, Yamada Eijiro, Pessin Jeffrey E

Abstract excerpt

The systems integration of whole-body metabolism and immune signaling are central homeostatic mechanisms necessary for maintenance of normal physiology, and dysregulation of these processes leads to a variety of chronic disorders. However, the intracellular mechanisms responsible for cell-autonomous cross-talk between the inflammatory signaling pathways and metabolic flux have remained enigmatic. In this study,...

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PMID: 29650758
DOI: 10.1074/jbc.RA118.002727
PMCID: PMC5961042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.