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Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm

16 Mar 2018

Abstract excerpt

STUDY QUESTION: Why are many sperm required for successful fertilization of oocytes in vitro, even though fertilization occurs in vivo when only a few sperm reach the oocyte? SUMMARY ANSWER: Creatine produced in the ovary promotes efficient fertilization in vivo; however, in vitro, creatine is not contained in the in vitro fertilization (IVF) medium. WHAT IS KNOWN ALREADY: The IVF medium enables capacitation of...

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PMID: 29635630
DOI: 10.1093/humrep/dey081

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