Article
Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI).
PloS one - 1 Jan 2018
Reed Jessica L, D'Ambrosio Enrico, Marenco Stefano, Ursini Gianluca, Zheutlin Amanda B, Blasi Giuseppe, Spencer Barbara E, Romano Raffaella, Hochheiser Jesse, Reifman Ann, Sturm Justin, Berman Karen F, Bertolino Alessandro, Weinberger Daniel R, Callicott Joseph H
Abstract excerpt
Brain phenotypes showing environmental influence may help clarify unexplained associations between urban exposure and psychiatric risk. Heritable prefrontal fMRI activation during working memory (WM) is such a phenotype. We hypothesized that urban upbringing (childhood urbanicity) would alter this phenotype and interact with dopamine genes that regulate prefrontal function during WM. Further, dopamine has been...
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