Article
β-Amyloid accumulation in the human brain after one night of sleep deprivation.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2018
Shokri-Kojori Ehsan, Wang Gene-Jack, Wiers Corinde E, Demiral Sukru B, Guo Min, Kim Sung Won, Lindgren Elsa, Ramirez Veronica, Zehra Amna, Freeman Clara, Miller Gregg, Manza Peter, Srivastava Tansha, De Santi Susan, Tomasi Dardo, Benveniste Helene, Volkow Nora D
Abstract excerpt
The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented. Here we used PET and 18F-florbetaben to measure brain Aβ burden (ABB) in 20 healthy controls tested after a night of rested sleep (baseline) and after a night of sleep deprivation. We show that one night of sleep deprivation, relative to baseline, resulted in a significant increase in Aβ burden in the...
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