Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia.

doi:10.1038/s41375-018-0092-2

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Article

Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia.

Leukemia - 1 Oct 2018

Gunnarsson Rebeqa, Dilorenzo Sebastian, Lundin-Ström Kristina B, Olsson Linda, Biloglav Andrea, Lilljebjörn Henrik, Rissler Marianne, Wahlberg Per, Lundmark Anders, Castor Anders, Behrendtz Mikael, Fioretos Thoas, Paulsson Kajsa, Isaksson Anders, Johansson Bertil

Abstract excerpt

High-throughput sequencing was applied to investigate the mutation/methylation patterns on 1q and gene expression profiles in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL) with/without (w/wo) dup(1q). Sequencing of the breakpoint regions and all exons on 1q in seven dup(1q)-positive cases revealed non-synonymous somatic single nucleotide variants (SNVs) in BLZF1, FMN2, KCNT2, LCE1C, NES, and...

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