Overexpressing human GPR109A leads to pronounced reduction in plasma triglyceride levels in BAC transgenic rats.

doi:10.1016/j.atherosclerosis.2018.03.041

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Article

Overexpressing human GPR109A leads to pronounced reduction in plasma triglyceride levels in BAC transgenic rats.

Atherosclerosis - 1 May 2018

Masuda Yusuke, Kurikawa Nobuya, Nishizawa Tomohiro

Abstract excerpt

BACKGROUND AND AIMS: Nicotinic acid administration causes plasma non-esterified fatty acid (NEFA) reduction and plasma lipid changes, including reduced triglyceride levels. GPR109A, which is expressed mainly in adipose tissue and has anti-lipolytic activity, was reported to be a molecular target for nicotinic acid. However, recent clinical reports have shown that most GPR109A agonists failed to induce clinically...

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Share to Chromosomes, Artificial, Bacterial
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 29625294
DOI: 10.1016/j.atherosclerosis.2018.03.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.