Article
Translational control of the undifferentiated phenotype in ER‑positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition.
Oncology reports - 1 Jun 2018
Vaklavas Christos, Zinn Kurt R, Samuel Sharon L, Meng Zheng, Grizzle William E, Choi Hyoungsoo, Blume Scott W
Abstract excerpt
Using a series of potential biomarkers relevant to mechanisms of protein synthesis, we observed that estrogen receptor (ER)-positive breast tumor cells exist in two distinct yet interconvertible phenotypic states (of roughly equal proportion) which differ in the degree of differentiation and use of IRES-mediated translation. Nascently translated IGF1R in the cytoplasm positively correlated with IRES activity and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.