FAM210A is a novel determinant of bone and muscle structure and strength.

doi:10.1073/pnas.1719089115

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Article

FAM210A is a novel determinant of bone and muscle structure and strength.

Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2018

Tanaka Ken-Ichiro, Xue Yingben, Nguyen-Yamamoto Loan, Morris John A, Kanazawa Ippei, Sugimoto Toshitsugu, Wing Simon S, Richards J Brent, Goltzman David

Abstract excerpt

Osteoporosis and sarcopenia are common comorbid diseases, yet their shared mechanisms are largely unknown. We found that genetic variation near FAM210A was associated, through large genome-wide association studies, with fracture, bone mineral density (BMD), and appendicular and whole body lean mass, in humans. In mice, Fam210a was expressed in muscle mitochondria and cytoplasm, as well as in heart and brain, but...

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Identifiers

PMID: 29618611
DOI: 10.1073/pnas.1719089115
PMCID: PMC5910842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.