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Article

GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance

4 Apr 2018

Abstract excerpt

The glycosylphosphatidylinositol-linked GDNF (glial cell derived neurotrophic factor) receptor alpha (GFRA), a coreceptor that recognizes the GDNF family of ligands, has a crucial role in the development and maintenance of the nervous system. Of the four identified GFRA isoforms, GFRA1 specifically recognizes GDNF and is involved in the regulation of proliferation, differentiation, and migration of neuronal...

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PMID: 29617307
DOI: 10.3390/ijms19041078

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