Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance ( <i>MDR1</i> ) gene

4 Apr 2018

Abstract excerpt

Resistance to chemotherapy hinders the successful treatment of acute lymphoblastic leukemia (ALL). The multi-drug resistance-1 (MDR1/ABCB1) gene encodes P‐glycoprotein (P-gp), which plays an important role in chemoresistance; however, its transcriptional regulation remains unclear. We investigated the role of YY1 in the regulation of MDR1 and its relation to ALL outcomes. Analysis of the MDR1 promoter revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Drug Transport and Resistance Mechanisms
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29616858
DOI: 10.1080/10428194.2018.1448083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance ( <i>MDR1</i> ) genePMID 29616858Read ↗

Yin Yang 1 (YY1) as a Central Node in Drug Resistance Pathways: Potential for Combination Strategies in Cancer TherapySemantic proximity Read ↗

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic targetSemantic proximity Read ↗

Overexpression of Yin Yang 1 in bone marrow-derived human multiple myeloma and its clinical significanceSemantic proximity Read ↗

A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic TargetsSemantic proximity Read ↗

Yin yang 1: a potential regulator of immune related diseases and cancer immunitySemantic proximity Read ↗

Role of YY1 in the Regulation of Anti-Apoptotic Gene Products in Drug-Resistant Cancer CellsSemantic proximity Read ↗

Molecular Pathways: Regulation and Therapeutic Implications of Multidrug ResistanceSemantic proximity Read ↗

Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer AnalysisSemantic proximity Read ↗

Crosstalk between YY1 and lncRNAs in cancer: A reviewSemantic proximity Read ↗

The basic and clinical implications of ABC transporters, Y‐box‐binding protein‐1 (YB‐1) and angiogenesis‐related factors in human malignanciesSemantic proximity Read ↗

Multifunctional transcription factor YY1: a therapeutic target in human cancer?Semantic proximity Read ↗

Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.