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Article

Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells.

Frontiers in immunology - 1 Jan 2018

Rotoli Bianca Maria, Barilli Amelia, Visigalli Rossana, Ingoglia Filippo, Milioli Marco, Di Lascia Maria, Riccardi Benedetta, Puccini Paola, Dall'Asta Valeria

Abstract excerpt

Lysinuric protein intolerance (LPI) is a recessively inherited aminoaciduria caused by mutations of SLC7A7, the gene encoding y+LAT1 light chain of system y+L for cationic amino acid transport. The pathogenesis of LPI is still unknown. In this study, we have utilized a gene silencing approach in macrophages and airway epithelial cells to investigate whether complications affecting lung and immune system are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29616026
DOI: 10.3389/fimmu.2018.00508
PMCID: PMC5868322

Genes

CCL5
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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