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Article

DNA methylation of the BRD 2 promoter is associated with juvenile myoclonic epilepsy in Caucasians

2 Apr 2018

Abstract excerpt

OBJECTIVE: Juvenile myoclonic epilepsy (JME) is a common adolescent-onset genetic generalized epilepsy (GGE) syndrome. Multiple linkage and association studies have found that BRD2 influences the expression of JME. The BRD2-JME connection is further corroborated by our murine model; Brd2 haploinsufficiency produces characteristics that typify the clinical hallmarks of JME. Neither we, nor several large-scale...

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PMID: 29608786
DOI: 10.1111/epi.14058

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