Article
Dolutegravir-based maintenance monotherapy versus dual therapy with lamivudine: a planned 24 week analysis of the DOLAM randomized clinical trial.
The Journal of antimicrobial chemotherapy - 1 Jul 2018
Blanco Jose L, Rojas Jhon, Paredes Roger, Negredo Eugenia, Mallolas Josep, Casadella Maria, Clotet Bonaventura, Gatell Jose M, de Lazzari Elisa, Martinez Esteban
Abstract excerpt
Background: No controlled comparisons between dolutegravir/lamivudine or dolutegravir maintenance therapy have been done. We hypothesized that these options would have similar efficacy to triple ART. Methods: We used an open-label non-inferiority randomized controlled trial comprising two phases: phase A was established to test that experimental arms did not have an unacceptable (≥5%) failure rate; phase B was...
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