Article
Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.
PloS one - 1 Jan 2018
Sugiyama Masakazu, Kikuchi Akihiro, Misu Hirofumi, Igawa Hirobumi, Ashihara Motooki, Kushima Youichi, Honda Kiyofumi, Suzuki Yoshiyuki, Kawabe Yoshiki, Kaneko Shuichi, Takamura Toshinari
Abstract excerpt
The liver plays a major role in whole-body energy homeostasis by releasing secretory factors, termed hepatokines. To identify novel target genes associated with insulin resistance, we performed a comprehensive analysis of gene expression profiles using a DNA chip method in liver biopsy samples from humans with varying degrees of insulin resistance. Inhibin βE (INHBE) was identified as a novel putative hepatokine...
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