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Article

Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase.

Nature communications - 28 Mar 2018

Li Fangfang, Zhang Changwei, Li Yinzi, Wu Guanwei, Hou Xilin, Zhou Xueping, Wang Aiming

Abstract excerpt

Autophagy emerges as an essential immunity defense against intracellular pathogens. Here we report that turnip mosaic virus (TuMV) infection activates autophagy in plants and that Beclin1 (ATG6), a core component of autophagy, inhibits virus replication. Beclin1 interacts with NIb, the RNA-dependent RNA polymerase (RdRp) of TuMV, via the highly conserved GDD motif and the interaction complex is targeted for...

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Identifiers

PMID: 29593293
DOI: 10.1038/s41467-018-03658-2
PMCID: PMC5871769

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