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Neurochemical abnormalities in premanifest and early spinocerebellar ataxias

25 Mar 2018

Abstract excerpt

OBJECTIVE: To investigate whether early neurochemical abnormalities are detectable by high-field magnetic resonance spectroscopy (MRS) in individuals with spinocerebellar ataxias (SCAs) 1, 2, 3, and 6, including patients without manifestation of ataxia. METHODS: A cohort of 100 subjects (N = 18-21 in each SCA group, including premanifest mutation carriers; mean score on the Scale for the Assessment and Rating of...

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PMID: 29575033
DOI: 10.1002/ana.25212

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