A genomics approach reveals insights into the importance of gene losses for mammalian adaptations.

doi:10.1038/s41467-018-03667-1

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Article

A genomics approach reveals insights into the importance of gene losses for mammalian adaptations.

Nature communications - 23 Mar 2018

Sharma Virag, Hecker Nikolai, Roscito Juliana G, Foerster Leo, Langer Bjoern E, Hiller Michael

Abstract excerpt

Identifying the genomic changes that underlie phenotypic adaptations is a key challenge in evolutionary biology and genomics. Loss of protein-coding genes is one type of genomic change with the potential to affect phenotypic evolution. Here, we develop a genomics approach to accurately detect gene losses and investigate their importance for adaptive evolution in mammals. We discover a number of gene losses that...

Topics

Adaptation, Physiological
Animals
Biodiversity
Biological Evolution
Cattle
Cetacea
Chiroptera
Dogs
Epidermis
Evolution, Molecular
Genome
Genomics
Mice
Mutation
Phenotype
Phylogeny
Rats
Species Specificity

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Open in PubMed Open full text

Identifiers

PMID: 29572503
DOI: 10.1038/s41467-018-03667-1
PMCID: PMC5865188

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